Paul Santoleri was born in Philadelphia, Pennsylvania. He earned his BFA in Painting from Tyler School of Art at Temple University in Philadelphia and Rome, Italy; an MFA in Painting from the University of Arizona in Tucson, and attended the Skowhegan School in Maine.
He exhibited his work internationally at Think Tank Gallery in Los Angeles, California; Foundation Gallery in New Orleans, Louisiana; Galerie Ligne13 in Paris, France; Kentler International Drawing Space in Brooklyn, New York; Galerie Nouveau in Santo Domingo, Dominican Republic; Pennsylvania Academy of Fine Arts in Philadelphia, Kunstraum Kreuzberg in Berlin, Germany; Takatsuki City Theatre in Japan, Galeria Aunkan in Barcelona, Spain; US Embassy in Damascus, Syria; and Fleisher Art Memorial in Philadelphia.
Santoleri received residencies at Chateau le Trosse Barriere in Briare, France; Islip Art Museum in New York, Brandywine Workshop, and Archives in Philadelphia, Pennsylvania; Montalvo Center for the Arts in Saratoga, California; and The Banff Centre in Alberta, Canada. He also received fellowships and grants from the Marie Walsh Sharpe Foundation, Independence Foundation in Philadelphia, Pollock-Krasner Foundation in New York, John Michael Kohler Art Center, Pennsylvania Council on the Arts, and a MacDowell Fellowship.
His work is in collections such as Centro Cultural Norteamericano Nicaraguense in Managua, Nicaragua; Claremont College Consortium in California, McDonald's’ Corporate Collection in King of Prussia, Pennsylvania; Odermatt Collection in Paris, France and Montreal, Canada; Philadelphia Museum of Art in Pennsylvania, Rhode Island School of Design Museum in Providence, Rhode Island; and the US Embassy in France.